Invitrogen™ PPY Polyclonal Antibody

The PPY gene encodes pancreatic polypeptide, a peptide hormone involved in the regulation of appetite and energy balance. The origin of the PPY gene is linked to a tandem duplication of the PYY gene, occurring concomitantly with the emergence of tetrapods, leading to the distinct PPY function within the neuropeptide Y family. In primates and ungulates, a gene duplication event resulted in the formation of a PYY2-PPY2 gene cluster, highlighting the evolutionary complexity of these genes. The PPY gene product is secreted by gamma-cells in the pancreas, localized primarily in the islet periphery, and plays a crucial role in metabolic homeostasis by interacting with receptors in the central nervous system to modulate satiety signals postprandially. PPY's function is linked to its inhibition of AGRP/NPY neurons which decreases their suppressive effect on POMC neurons, enhancing POMC activity and contributing to appetite suppression. This intricate regulation underscores the importance of PPY in dietary intake and metabolic disorders, with ongoing research exploring its potential therapeutic applications.