Invitrogen™ PP1 alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (HL1677)

Descripción

Store as concentrated solution. Centrifuge briefly prior to opening vial.

PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription Increased PP1 activity has been observed in the end stage of heart failure Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer PP1 alpha is one of the three catalytic subunits of protein phosphatase 1 (PP1) This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity PP1 beta encodes the beta isozyme and PP1 gamma encodes the gamma isozyme.