Invitrogen™ PODXL Monoclonal Antibody (5D4)

Descripción

MA5-15845 targets PODXL in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15845 immunogen is purified recombinant fragment of human PODXL expressed in E. Coli. . MA5-15845 detects PODXL which has a predicted molecular weight of approximately 49kDa.

This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.