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PIAS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Código de producto. 16841724 Tienda Proteintech Productos
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150 μL
20 μL
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150 microlitros
20 microlitros
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Código de producto. 16841724 Proveedor Proteintech N.º de proveedor 134861AP20UL

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Descripción

Rabbit Polyclonal Antibody

The PIAS3 antibody detects PIAS3 (68 kDa) as well as its sumoylated form (85 kDa) in some normal mouse tissues, breast and brain tumor cell lines.

The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.

Especificaciones

Antígeno PIAS3
Aplicaciones Immunofluorescence, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clasificación Polyclonal
Concentración 0.23 mg/mL
Conjugado Unconjugated
Formulación PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
génica PIAS3
N.º de referencia del gen O54714, O70260, Q9Y6X2
Alias de gen E3 SUMO protein ligase PIAS3, PIAS3, ZMIZ5
Símbolos de los genes PIAS3
Especie del huésped Rabbit
Inmunógeno PIAS3 Fusion Protein Ag4304
Método de purificación Antigen Affinity Chromatography
Cantidad 20 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 10401, 229615, 83614
Especies diana Mouse, Human, Rat
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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