missing translation for 'onlineSavingsMsg'
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Invitrogen™ Phospho-ULK1 (Ser555) Polyclonal Antibody

Descripción
Positive Control: MCF-7, MCF-7 (100 μM CCCP treatment for 2 hr) Predicted Reactivity: Mouse (100%), Rat (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Especificaciones
Especificaciones
| Antígeno | Phospho-ULK1 (Ser555) |
| Aplicaciones | Western Blot |
| Clasificación | Polyclonal |
| Concentración | 0.13 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7 |
| génica | ULK1 |
| N.º de referencia del gen | O75385 |
| Alias de gen | APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; ATG1A; AU041434; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; hATG1; KIAA0722; mKIAA0722; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; ULK 1; Ulk1; UNC 51; UNC51; unc-51 like autophagy activating kinase 1; unc-51 like kinase 1; Unc51.1; unc-51-like kinase 1 |
| Símbolos de los genes | ULK1 |
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Título del producto
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