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Invitrogen™ Phospho-STAT6 (Tyr641) Recombinant Rabbit Monoclonal Antibody (46H1L12)

Código de producto. 15356954
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
Código de producto. Cantidad unitSize
15356954 100 μg 100 microgramos
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Código de producto. 15356954

Marca: Invitrogen™ 700247

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Descripción

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Rhesus monkey, orangutan, bovine, canine, mouse and rat based on sequence homology. Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Phospho-STAT6 (Tyr641)
Aplicaciones ChIP Assay, ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Clasificación Recombinant Monoclonal
Clon 46H1L12
Concentración 0.5 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.09% sodium azide
génica STAT6
N.º de referencia del gen P42226, P52633
Alias de gen 12S1644; D12S1644; IL4 STAT; IL-4 Stat; IL-4-STAT; signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; signal transducer and transcription activator 6; STAT; STAT, interleukin4-induced; Stat6; STAT-6; STAT6B; STAT6C; transcription factor IL-4 STAT
Símbolos de los genes STAT6
Especie del huésped Rabbit
Inmunógeno A peptide corresponding to amino acids 636-645 of P42226.
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 20852, 6778
Especies diana Human, Mouse
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
Características ecológicas Responsibly packaged
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