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Invitrogen™ Phospho-Paxillin (Tyr118) Polyclonal Antibody

Código de producto. 10088522
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Cantidad:
100 μL
Tamaño de la unidad:
cada uno
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10088522 100 μL cada uno
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Código de producto. 10088522 Proveedor Invitrogen™ N.º de proveedor 44722G

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Descripción

Rabbit Polyclonal Antibody

The antibody has been negatively preadsorbed using i) a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated paxillin, and ii) a generic tyrosine phosphorylated peptide to remove antibody that is reactive with phosphotyrosine, irrespective of the sequence. The final product is generated by affinity chromatography using a paxillin-derived peptide that is phosphorylated at tyrosine 118. Positive controls used with this antibody in western blotting were normal mouse mammary gland (NMuMG) cells, NMuMG transfected with EGFP-tagged paxillin +/- TGFbeta, and human epidermoid carcinoma cells (A431) +/- EGF.

Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Phospho-Paxillin (Tyr118)
Aplicaciones Immunohistochemistry, Western Blot
Clasificación Polyclonal
Conjugado Unconjugated
Formulación Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
génica PXN
N.º de referencia del gen P49023, Q8VI36
Alias de gen adaptor protein; AW108311; AW123232; FLJ16691; hCG_1778014; I79_001229; myocardial ischemic preconditioning associated protein 7; Pax; PAX-1; PAXI; Paxillin; paxillin a; paxillin alpha; pxn; pxna; testicular tissue protein Li 134; TGFB1I1; transforming growth factor beta 1 induced transcript 1; wu:fw71f12
Símbolos de los genes PXN
Especie del huésped Rabbit
Inmunógeno The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human paxillin that contains tyrosine 118.
Método de purificación Antigen affinity chromatography
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 19303, 5829
Especies diana Human, Mouse
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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