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Invitrogen™ Phospho-PAK2 (Ser20) Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA517749
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Descripción
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other phosphorylated PAK family members.
PAK2 (serine/threonine-protein kinase PAK2) is a serine/threonine kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, or proliferation. It acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformation change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.
Especificaciones
| Phospho-PAK2 (Ser20) | |
| Polyclonal | |
| Unconjugated | |
| Pak2 | |
| 5330420P17Rik; A130002K10Rik; AI836325; Alpha-PAK; Beta-PAK; C-t-PAK2; D16Ertd269e; gamma pak; gamma-PAK; mKIAA4182; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 2; p21 (RAC1) activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p27; p34; p58; p65-PAK; PAK alpha; PAK beta; PAK gamma; PAK1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK65; PAKgamma; S6/H4 kinase; serine/threonine-protein kinase PAK 2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 224105, 29432, 5062 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 228 μg/mL | |
| 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| Q13177, Q64303, Q8CIN4 | |
| Pak2 | |
| Synthetic phosphopeptide corresponding to residues surrounding pSer20 of human PAK2. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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