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Phospho-NCF4 (Thr154) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA538379
Detalles adicionales : Peso : 0.00900kg
Descripción
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.Especificaciones
Phospho-NCF4 (Thr154) | |
Polyclonal | |
Unconjugated | |
NCF4 | |
NCF, P40PHOX, SH3PXD4, NCF-4, SH3 and PX domain-containing protein 4, neutrophil NADPH oxidase factor 4, neutrophil cytosol factor 4, p40-phox | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
17972, 4689 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin) | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q15080, P97369 | |
NCF4 | |
A synthetic phosphopeptide derived from human p40 phox around the phosphorylation site of Thr154 (P-R-TP-R-K) | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |