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Phospho-ICAM-3 (Ser518) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA538450
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Descripción
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
Especificaciones
| Phospho-ICAM-3 (Ser518) | |
| Polyclonal | |
| Unconjugated | |
| ICAM3 | |
| CD50, CDW50, ICAM-R, ICAM-3, intercellular adhesion molecule-3 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 3385 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P32942 | |
| ICAM3 | |
| A synthetic phosphopeptide derived from human CD50/ICAM-3 around the phosphorylation site of Ser518 (S-G-SP-Y-H) | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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