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Invitrogen™ Phospho-DOK1 (Tyr362) Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA536845
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Beskrivning
This antibody detects endogenous protein at a molecular weight of 62 kDa. Purity is >95% by SDS-PAGE.
DOK1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.
Specifikationer
| Phospho-DOK1 (Tyr362) | |
| Polyclonal | |
| Unconjugated | |
| DOK1 | |
| AW557123; Docking protein 1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); Dok; DOK 1; DOK1; Dok-1; Downstream of tyrosine kinase 1; downstream of tyrosine kinase-1; MGC117395; MGC138860; p240; p62 dok; p62(dok); p62DOK; pp62; TLP1; TP1; TROVE domain family; TROVE1; VAULT2 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 13448, 1796, 312477 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry, Immunocytochemistry, Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
| P97465, Q4QQV2, Q99704 | |
| DOK1 | |
| Synthetic phosphopeptide derived from human Dok-1 around the phosphorylation site of Tyrosine 362. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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