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Invitrogen™ Phospho-c-Cbl (Tyr700) Recombinant Rabbit Monoclonal Antibody (CblY700-E1), Invitrogen™
Tienda Thermo Scientific Productos

Descripción
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Especificaciones
Especificaciones
| Antígeno | Phospho-c-Cbl (Tyr700) |
| Aplicaciones | Flow Cytometry |
| Clasificación | Recombinant Monoclonal |
| Clon | CblY700-E1 |
| Concentración | 0.5 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide |
| génica | Cbl |
| N.º de referencia del gen | P22681, P22682 |
| Alias de gen | 4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL |
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Título del producto
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