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  6. Invitrogen™ Phospho-beta Arrestin 1 (Ser412) Recombinant Rabbit Monoclonal Antibody (23GB3845), Invitrogen™

Invitrogen™ Phospho-beta Arrestin 1 (Ser412) Recombinant Rabbit Monoclonal Antibody (23GB3845), Invitrogen™
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Product Code. p-200087740
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Cantidad:
20 μL
100 μL
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100 microlitros
20 microlitros
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Product Code. Cantidad unitSize
30087664 100 μL 100 microlitros
30088391 20 μL 20 microlitros
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Product Code. 30087664 missing translation for 'mfr' Invitrogen™ missing translation for 'supplierNo' MA553648

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Description

Rabbit Recombinant Monoclonal Antibody

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antígeno Phospho-beta Arrestin 1 (Ser412)
Aplicaciones Flow Cytometry, Western Blot, Immunocytochemistry
Clasificación Recombinant Monoclonal
Clon 23GB3845
Conjugado Unconjugated
Formulación PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
génica ARRB1
N.º de referencia del gen P49407
Alias de gen 1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2
Símbolos de los genes ARRB1
Especie del huésped Rabbit
Inmunógeno A synthetic peptide of human Phospho-beta Arrestin 1 (Ser412) (405-418AA).
Método de purificación Affinity Chromatography
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 408
Especies diana Human
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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