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Phospho-53BP1 (Ser25) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA538465
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Descripción
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
Especificaciones
| Phospho-53BP1 (Ser25) | |
| Polyclonal | |
| Unconjugated | |
| TP53BP1 | |
| p202, p53-binding protein 1, tumor protein 53-binding protein, tumor suppressor p53-binding protein 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 27223, 296099, 7158 | |
| -20°C | |
| Liquid |
| Peptide ELISA, Immunofluorescence, Immunohistochemistry (Paraffin) | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q12888, P70399 | |
| TP53BP1, Trp53bp1 | |
| A synthetic phosphopeptide derived from human 53BP1 around the phosphorylation site of Ser25 (E-D-SP-Q-P) | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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