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Invitrogen™ Phl p 1 Chimeric Recombinant Human Monoclonal Antibody (Clone 25)
Descripción
This antibody binds to the Timothy grass allergen Phl p 1 and shows cotss reactivity with natural group 1 allergens from a variety of grass species such as oat, sweet vernal grass, Bermuda grass, rye grass, common reed, Kentucky blue grass, rye, wheat and maize (weak).
Phl p 1 binds to specific receptors on the surface of immune cells called TLR4 (Toll-like receptor 4) and MD-2 (myeloid differentiation factor 2). This binding triggers a signaling cascade that leads to the activation of immune cells and the release of inflammatory mediators, which cause the allergic symptoms. The interaction between Phl p 1 and TLR4-MD-2 complex has been studied extensively and is considered a key event in the development of grass pollen allergy. Understanding the molecular mechanisms involved in this interaction is important for developing new therapeutic strategies to treat or prevent allergic reactions.
Especificaciones
Especificaciones
| Antígeno | Phl p 1 Chimeric |
| Aplicaciones | Dot Blot, ELISA, Western Blot |
| Clasificación | Recombinant Monoclonal |
| Clon | Clone 25 |
| Concentración | 1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 0.02% ProClin 300 |
| Alias de gen | Group 1 grass pollen allergen; Phleum pratense allergen 1; Timothy grass pollen allergen |
| Especie del huésped | Human |
| Inmunógeno | Recombinant Phl p 1, a grass pollen allergen. |
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Título del producto
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