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Invitrogen™ PDK4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA522983
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Descripción
Immunogen sequence homology: rat (94%), bovine (100%). Not recommended for ICC, as nonspecific nuclear staining was observed in HeLa cells.
PDK4 (PDHK4), along with the other PDHKs, regulates glucose metabolism by phosphorylating the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex. Inhibition of PDHKs is viewed as a potential therapeutic treatment for type II diabetes. This protein is located in the matrix of the mitrochondria and it's expression is regulated by glucocorticoids, retinoic acid and insulin. PDK4 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
Especificaciones
| PDK4 | |
| Polyclonal | |
| Unconjugated | |
| Pdk4 | |
| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; AV005916; kinase isozyme 4; lipoamide; PDHK4; Pdk4; pyruvate dehydrogenase; pyruvate dehydrogenase kinase 4; Pyruvate dehydrogenase kinase isoform 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; pyruvate dehydrogenate kinase 4 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 27273, 5166 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1.0 mg/mL | |
| PBS with 30% glycerol and 0.1% sodium azide | |
| O70571, Q16654 | |
| Pdk4 | |
| Synthetic peptide made to an internal portion of the human PDK4 protein (within residues 100-150). | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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