PD-L2 (PDCD1LG2) Monoclonal Antibody (OTI12C7), TrueMAB™, OriGene

Descripción

CD273 (PDCD1 Ligand 2, Programmed cell death 2 ligand 2, PD-L2, B7-DC) is involved in cell-mediated immune responses initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as CD273 that mediate inhibitory signals from the APC (antigen presenting cell). CD273 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; CD273 is specific to the largest isoform. Diseases associated with CD273 include cysticercosis, and myasthenic syndrome.