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NOTCH3 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA513203
Detalles adicionales : Peso : 0.01000kg
Descripción
This antibody is predicted to react with human based on sequence homology.
NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).Especificaciones
NOTCH3 | |
Polyclonal | |
Unconjugated | |
Notch3 | |
AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3 | |
Rabbit | |
Ammonium sulfate precipitation, Size-exclusion - Dialysis | |
RUO | |
18131, 4854 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
2 mg/mL | |
PBS with 0.09% sodium azide | |
Q61982, Q9UM47 | |
Notch3 | |
KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3 | |
400 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |