Invitrogen™ NOD4 Polyclonal Antibody

Descripción

Immunogen sequence: GLVRCFSTLQW LFRLDISFES QHILLRGDKT SRDMWATGSL PDFPAAAKFL GFRQRCIPRS LCLSECPLEP PSLTRLCATL KDCPGPLELQ LSCEFLSDQ Highest antigen sequence identity to the following orthologs - mouse 55%, rat 50%.

NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-kappa-B and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.