missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ NO66 Polyclonal Antibody
Descripción
Predicted to react with Mouse and Rat samples.
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt].
Especificaciones
Especificaciones
| Antígeno | NO66 |
| Aplicaciones | Immunohistochemistry (Paraffin) |
| Clasificación | Polyclonal |
| Concentración | 1.1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 40% glycerol and 0.05% sodium azide; pH 7.4 |
| génica | RIOX1 |
| N.º de referencia del gen | D3ZU57, Q9H6W3, Q9JJF3 |
| Alias de gen | 2410016O06Rik; 60S ribosomal protein L8 histidine hydroxylase; bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; C14orf169; chromosome 14 open reading frame 169; FLJ21802; histone lysine demethylase NO66; hsNO66; lysine-specific demethylase NO66; Mapjd; MNCb-7109; myc associated protein with JmjC domain; MYC-associated protein with JmjC domain; NO66; nucleolar protein 66; RGD1307704; Ribosomal oxygenase 1; Ribosomal oxygenase NO66; RIKEN cDNA 2410016O06 gene; Riox1; ROX; similar to RIKEN cDNA 2410016O06; up-regulated in lung cancer 2; URLC2 |
| Símbolos de los genes | RIOX1 |
| Mostrar más |
Título del producto
Al hacer clic en Enviar, acepta que Fisher Scientific se ponga en contacto con usted en relación con los comentarios que ha proporcionado en este formulario. No compartiremos su información para ningún otro fin. Toda la información de contacto proporcionada se mantendrá de acuerdo con nuestra Política de Privacidad. Política de privacidad.
¿Detecta una oportunidad de mejora?