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Invitrogen™ Nhe-1 Polyclonal Antibody
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Código de producto. 17228973 Tienda Thermo Scientific Productos
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Cantidad:
100 μL
Tamaño de la unidad:
100 microlitros
Código de producto. Cantidad unitSize
17228973 100 μL 100 microlitros
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Código de producto. 17228973

Marca: Invitrogen™ PA5116471

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Descripción

Rabbit Polyclonal Antibody

Positive controls: Rat skin lysates, A431, 293T, LOVO, human kidney tissue, mouse colon tissue, human small intestine tissue.

The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Nhe-1
Aplicaciones Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Clasificación Polyclonal
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
génica SLC9A1
N.º de referencia del gen P19634, P26431, Q61165
Alias de gen Apnh; APNH1; AW554487; LIKNS; Mir5122; mir-5122; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; Na-Li countertransporter; Nhe1; NHE-1; PPP1R143; protein phosphatase 1, regulatory subunit 143; SLC9A1; slow-wave epilepsy; sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 member 1; solute carrier family 9 member A1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; swe
Símbolos de los genes SLC9A1
Especie del huésped Rabbit
Inmunógeno Synthetic peptide within mouse NHE-1 aa 36-85.
Método de purificación Antigen affinity chromatography
Cantidad 100 μL
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 20544, 24782, 6548
Especies diana Human, Mouse, Rat
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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