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Nestin Mouse, anti-Human, Unconjugated, Clone: 10C2, STEMCELL Technologies
Descripción
- The 10C2 antibody reacts with human nestin, a class VI intermediate filament (IF) protein expressed by embryonic neuroepithelial stem cells in the developing nervous system and by pancreatic islet and mesenchymal progenitor cells
- Nestin expression is also observed in glioblastomas and many primary and metastatic melanomas and it is a useful angiogenic marker to evaluate neovascularity of endothelial cells in tumors
- Nestin is required for the survival and renewal of neural progenitor cells and plays roles in cellular remodeling by forming heterodimers with vimentin or alpha-internexin, a process that appears to be tightly regulated by phosphorylation
- Nestin localizes to the growth cones during axon elongation in differentiating neurons and may play a role in growth cone guidance
- Nestin expression is down-regulated during differentiation, typically disappearing by embryonic stage E18
- The 10C2 antibody reportedly cross-reacts weakly with monkey nestin but not rodent nestin
Especificaciones
Especificaciones
| Antígeno | Nestin |
| Aplicaciones | Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence |
| Clasificación | Monoclonal |
| Clon | 10C2 |
| Conjugado | Unconjugated |
| Especie del huésped | Mouse |
| Cantidad | 25 μg |
| Primario o secundario | Primary |
| Especies diana | Cynomolgus, Human |
| Isotype | IgG1 κ |
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Título del producto
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