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Invitrogen™ Munc13-4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA5119767
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Descripción
Positive Control: Jurkat cell lysate, K562 cell lysate, rat lung tissue lysate, Hela, SHSY5Y, rat spleen tissue, human placenta tissue. Subcellular Location: Cytoplasm, Endosome, Lysosome, Membrane.
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Especificaciones
| Munc13-4 | |
| Polyclonal | |
| Unconjugated | |
| Unc13d | |
| 2610108D09Rik; FHL3; HLH3; HPLH3; Jinx; likely ortholog of H. sapiens unc-13 homolog D (UNC13D); mFLJ00067; munc 13-4; Munc13-4; Protein unc-13 homolog D; unc-13 homolog D; unc-13 homolog D (C. elegans); Unc13d | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 192177, 201294 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4 | |
| Q70J99, Q9R189 | |
| Unc13d | |
| Recombinant protein within human Munc13-4 aa 900-1090. | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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