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Invitrogen™ MTBP Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA530522
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Descripción
Recommended positive controls: Jurkat, THP-1, HL-60. Predicted reactivity: Mouse (81%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. The protein inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of TP53/p53 and its subsequent degradation.
Especificaciones
| MTBP | |
| Polyclonal | |
| Unconjugated | |
| Mtbp | |
| AI429604; hdm2; HDMX; hMTBP; MDM2 (mouse double minute 2)-binding protein, 104kD; MDM2 binding protein; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; Mdm2, transformed 3T3 cell double minute p53 binding protein; mdm2-binding protein; MDM2BP; MGC5370; MGC71221; mMTBP; Mtbp; RGD1565672 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 27085 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q96DY7 | |
| Mtbp | |
| Recombinant protein encompassing a sequence within the center region of human MTBP. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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