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Invitrogen™ MSK1 Polyclonal Antibody
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Código de producto. 16374485 Tienda Thermo Scientific Productos
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
Código de producto. Cantidad unitSize
16374485 100 μg 100 microgramos
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Código de producto. 16374485

Marca: Invitrogen™ PA595219

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Descripción

Rabbit Polyclonal Antibody

Human MSK1 shares 98% amino acid (aa) sequence identity with mouse MSK1. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human HEL whole cell, rat brain tissue, mouse brain tissue. IHC: Mouse Cardiac Muscle tissue, Rat Brain tissue, Human Placenta tissue. ICC/IF: T47D cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

RPS6KA5 (MSK1) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. RPS6KA5 is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno MSK1
Aplicaciones Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Clasificación Polyclonal
Concentración 500 μg/mL
Conjugado Unconjugated
Formulación PBS with 5mg BSA and 0.05mg sodium azide
génica Rps6ka5
N.º de referencia del gen O75582, Q8C050
Alias de gen 3110005L17Rik; 6330404E13Rik; 90 kDa ribosomal protein S6 kinase 5; AI854034; kinase MSK1; KS6A5; mitogen and stress-activated protein kinase 1; Msk1; MSPK1; Nuclear mitogen- and stress-activated protein kinase 1; ribosomal protein S6 kinase A5; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; ribosomal protein S6 kinase, polypeptide 5; RLPK; RLSK; Rps6ka5; RSKL; RSK-like protein kinase; S6K-alpha-5
Símbolos de los genes Rps6ka5
Especie del huésped Rabbit
Inmunógeno E.coli-derived human MSK1 recombinant protein (Position: V540-Q665).
Método de purificación Affinity chromatography
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 314384, 73086, 9252
Especies diana Human, Mouse, Rat
Contenido y almacenamiento -20°C
Tipo de producto Antibody
Formulario Lyophilized
Isotype IgG
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