Invitrogen™ MPST Polyclonal Antibody

Descripción

Immunogen sequence: LVSAQWVAEA LRAPRAGQPL QLLDASWYLP KLGRDARREF EERHIPGAAF FDIDQCSDRT SPYDHMLPGA EHFAEYAGRL GVGAATHVVI YDASDQGLYS APRVWWMFRA FGHHAVSLLD GGLRHWLRQN LPLSSGKSQP A; Positive Samples: Mouse liver, Rat liver; Cellular Location: Cell junction, Cytoplasm, Mitochondrion, synapse, synaptosome.

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene.