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MAPK10, Mouse, Clone: 8A5D11, Abnova™
Mouse monoclonal antibody raised against partial recombinant MAPK10.
Marca: Abnova MAB5534.100ug
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Descripción
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Especificaciones
| MAPK10 | |
| Monoclonal | |
| Unconjugated | |
| Western Blot (1:500-1:1000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000) ELISA (1:10000) The optimal working dilution should be determined by the end user. | |
| MAPK10 | |
| MAPK10 | |
| Recombinant protein corresponding to human MAPK10. | |
| RUO | |
| 5602 | |
| Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
|
| IgG1 |
| ELISA, Immunohistochemistry, Western Blot | |
| 8A5D11 | |
| Mouse monoclonal antibody raised against partial recombinant MAPK10. | |
| In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide) | |
| FLJ12099/FLJ33785/JNK3/JNK3A/MGC50974/PRKM10/p493F12/p54bSAPK | |
| Mouse | |
| 100 μg | |
| Primary | |
| Human | |
| Liquid |
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