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DAG1, Mouse, Clone: M117, Abnova™
Mouse monoclonal antibody raised against synthetic phosphopeptide of DAG1.
Marca: Abnova MAB1368.100uL
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Descripción
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants
Especificaciones
| DAG1 | |
| Monoclonal | |
| Unconjugated | |
| ELISA (1:2000) Western Blot (1:500) The optimal working dilution should be determined by the end user. | |
| DAG1 | |
| DAG1 | |
| Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y892 of human DAG1. | |
| RUO | |
| 1605 | |
| Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
|
| IgG1 |
| ELISA, Western Blot | |
| M117 | |
| Mouse monoclonal antibody raised against synthetic phosphopeptide of DAG1. | |
| In PBS (50% glycerol, 1mg/mL BSA, 0.05% sodium azide) | |
| 156DAG/A3a/AGRNR/DAG | |
| Mouse | |
| 100 μL | |
| Primary | |
| This peptide sequence has high homology to the conserved tyrosine site in rat and mouse dystroglycan. | |
| Liquid |
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