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CD39 Mouse anti-Human, PerCP-Cy5.5, Clone: TU66, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 564899
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Descripción
The TU66 monoclonal antibody reacts with human CD39 also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) an ectoenzyme that degrades ATP to AMP. It is a member of the family of ectonucleoside triphosphate dihydrolases (E-NTPDases) known to be involved in regulation of extracellular nucleotide catabolism, controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is expressed on a subset of T cells, B cells and dendritic cells with weak staining of monocytes and granulocytes. Recently, CD39 has been found to be expressed primarly by immune-suppressive Foxp3(+) regulatory T (Treg) cells in both human and mice. In humans, CD39 is restricted to a subset of Foxp3+ regulatory effector/memory-like T cells. In mice, the enzyme is present on most if not all CD4+CD25+ cells and CD39 expression is driven by Foxp3. It is thought that CD39 allows Treg cells to enter inflamed areas where high levels of ATP are present.
Especificaciones
| CD39 | |
| Monoclonal | |
| PerCP-Cyanine5.5 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Affinity Purified | |
| RUO | |
| Human | |
| IgG2b κ |
| Flow Cytometry | |
| TU66 | |
| ENTPD1; NTPDase-1; Ecto-ATPase 1; Ecto-ATPDase 1 | |
| Mouse | |
| 100 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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