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CCND1, Mouse, Clone: CD1.1, Abnova™
Mouse monoclonal antibody raised against CCND1.
Marca: Abnova MAB6501.100ug
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Descripción
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
Especificaciones
| CCND1 | |
| Monoclonal | |
| Unconjugated | |
| Flow Cytometry Immunocytochemistry (1 ug/mL) Immunohistochemistry (2 ug/mL) Immunoprecipitation (1 ug/mL) Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user. | |
| CCND1 | |
| CCND1 | |
| Purified cyclin D1 protein. | |
| RUO | |
| 595 | |
| Human, Rat | |
| Liquid |
| Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot | |
| CD1.1 | |
| Mouse monoclonal antibody raised against CCND1. | |
| In PBS, pH 7.4 (0.09% sodium azide) | |
| BCL1/D11S287E/PRAD1/U21B31 | |
| Mouse | |
| 100 μg | |
| Primary | |
| This antibody recognizes CCND1, an ubiquitously expressed 33 KDa protein thatmigrates as a 36 KDa band under reducing SDS-PAGE conditions. | |
| Store at 4°C. Do not freeze. Aliquot to avoid repeated freezing and thawing. |
|
| IgG1 |
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