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MBD1 Monoclonal Antibody (OTI2H5), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Marca: Origene Technologies TA811767
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Descripción
Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription form unmethylated promoters.Especificaciones
| MBD1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9UIS9 | |
| MBD1 | |
| Human recombit protein fragment corresponding to amino acids 222-556 of human MBD1 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| OTI2H5 | |
| Unconjugated | |
| MBD1 | |
| CXXC3, PCM1, RFT | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 4152 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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