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Invitrogen™ MARK1 Polyclonal Antibody

Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA529402
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Descripción
Recommended positive controls: A431, H1299, HeLa. Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (94%), Xenopus laevis (96%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Especificaciones
| MARK1 | |
| Polyclonal | |
| Unconjugated | |
| MARK1 | |
| AW491150; B930025N23Rik; ELKL motif serine/threonine-protein kinase 3; ELKL motif serine-threonine protein kinase 3; Emk3; KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; mark1 {ECO:0000312; microtubule affinity regulating kinase 1; mKIAA1477; mPar-1c; PAR1 homolog c; Par1c; Par-1c; RGD:619882}; serine/threonine-protein kinase MARK1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 4139 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| Q9P0L2 | |
| MARK1 | |
| Recombinant protein encompassing a sequence within the N-terminus region of human MARK1. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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