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Invitrogen™ MARK1 Polyclonal Antibody

Descripción
Immunogen sequence: QEEEELKPYT EPDPDFNDTK RIDIMVTMGF ARDEINDALI NQKYDEVMAT YILLGRKPPE FEGGESLSSG NLCQRSRPSS DLNNSTLQSP AHLKVQRSIS ANQKQRRFSD HAGPSIPPAV SYTKRPQANS VESEQK Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 94%.
MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Especificaciones
Especificaciones
| Antígeno | MARK1 |
| Aplicaciones | Immunohistochemistry (Paraffin) |
| Clasificación | Polyclonal |
| Concentración | 0.1 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| génica | MARK1 |
| N.º de referencia del gen | Q9P0L2 |
| Alias de gen | AW491150; B930025N23Rik; ELKL motif serine/threonine-protein kinase 3; ELKL motif serine-threonine protein kinase 3; Emk3; KIAA1477; MAP/microtubule affinity regulating kinase 1; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; mark1 {ECO:0000312; microtubule affinity regulating kinase 1; mKIAA1477; mPar-1c; PAR1 homolog c; Par1c; Par-1c; RGD:619882}; serine/threonine-protein kinase MARK1 |
| Símbolos de los genes | MARK1 |
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Título del producto
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