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Invitrogen™ LIMP2 Recombinant Rabbit Monoclonal Antibody (22H6L14)

Código de producto. 16143517
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
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16143517 100 μg 100 microgramos
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Código de producto. 16143517 Proveedor Invitrogen™ N.º de proveedor 703037

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Descripción

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Rat, Rabbit. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno LIMP2
Aplicaciones Western Blot, Immunocytochemistry
Clasificación Recombinant Monoclonal
Clon 22H6L14
Concentración 0.5 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.09% sodium azide; pH 7.4
génica SCARB2
N.º de referencia del gen Q14108
Alias de gen 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; 9330185J12Rik; AMRF; CD 36; CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen-like 2; CD36 molecule; Cd36l2; EPM4; HLGP85; I79_021583; LGP85; LIMP II; LIMP2; LIMP-2; LIMPII; Lysosome membrane protein 2; lysosome membrane protein II; MLGP85; Scarb2; Scavenger receptor class B member 2; scavenger receptor class B, member 2; sCD 36; sCD36; soluble CD 36; soluble CD36; SR-B2; SR-BII
Símbolos de los genes SCARB2
Especie del huésped Rabbit
Inmunógeno Protein corresponding to human SCARB2 [aa35-aa430].
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 950
Especies diana Human
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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