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  5. STEMCELL Technologies Lapatinib​

STEMCELL Technologies Lapatinib​

Código de producto. p-7217745
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Cantidad:
10 mg
Tamaño de la unidad:
10 miligramos
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Código de producto. 17130192

Marca: STEMCELL Technologies 73242

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Descripción

Tyrosine kinase inhibitor; Inhibits EGFR and HER2

  • Lapatinib is a selective dual inhibitor of epidermal growth factor receptor (EGFR, ERBB1) and human epidermal growth factor receptor 2 (HER2, ERBB2), each with an IC50 of about 10 nM (Rusnak et al.) It binds reversibly, but with a very slow off-rate, to the ATP binding pocket in an inactive-like conformation, thus preventing autophosphorylation
  • Binding is very potent, with Ki values of 3 and 13 nM to EGFR and HER2 respectively (Wood et al.)
  • Induces apoptosis in cells overexpressing EGFR and/or HER2, and inhibits tumor growth in a mouse xenograft model (Xia et al.)

Specifications

CAS 231277-92-2
Sinónimo GSK 572016; GW 572016; Tyverb; GW2016
Cantidad 10 mg
Fórmula molecular C29H26ClFN4O4S
Pureza ≥98%
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