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LAIR-1 (CD305) Mouse anti-Human, Brilliant Violet 510, Clone: DX26, BD Optibuild™

Código de producto. 15819139
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Cantidad:
50 μg
Tamaño de la unidad:
cada uno
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15819139 50 μg cada uno
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Código de producto. 15819139 Proveedor BD Biosciences N.º de proveedor 744558

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Descripción

Mouse Monoclonal Antibody

The DX26 monoclonal antibody specifically binds to Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1/ hLAIR1/Leukocyte-associated Ig-like receptor 1) that is encoded by LAIR1, /and also known as, CD305. LAIR-1 is a ñ32 kDa type I transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory (ITIM) motifs. LAIR-1 is expressed on T cells, B cells, NK cells, monocytes, and dendritic cells. LAIR-1 recruits SHP-1 and SHP-2 tyrosine phosphatases upon activation. Crosslinking of the LAIR-1 expressed on T cells or NK cells can result in strong inhibition of cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize MHC class I molecules and thus represents a novel MHC class I-independent mechanism of NK cell regulation.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser. BV510 is a polymer-based dye that is brighter than BD Horizon V500. Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno LAIR-1 (CD305)
Clasificación Monoclonal
Clon DX26
Concentración 0.2mg/mL
Conjugado Brilliant Violet 510
Formulación Aqueous buffered solution containing ≤0.09% sodium azide.
Alias de gen CD305, LAIR1, hLAIR1, Leukocyte-associated Ig-like receptor 1
Especie del huésped Mouse
Inmunógeno Human NK Cell Clone
Método de purificación Affinity Purified
Cantidad 50 μg
Estado normativo RUO
Primario o secundario Primary
Especies diana Human
Contenido y almacenamiento Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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