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DOG1 Mouse Monoclonal Antibody, Epredia™

Product Code. 12680487 Shop All Epredia Products
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Cantidad:
100 μL
1 mL
7 mL
12 mL
Formulario:
Purified
Ready-to-Use
Unit Size:
1 ml
100 microlitros
12 ml
7 ml
Product Code. Cantidad Formulario unitSize
12680487 1 mL Purified 1 ml
12670487 100 μL Purified 100 microlitros
12600497 7 mL Ready-to-Use 7 ml
12610497 12 mL Ready-to-Use 12 ml
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Product Code. 12680487

Brand: Epredia MS1933P

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This item is not returnable. View return policy

Description

Obtain accurate, reproducible results in immunohistochemistry experiments with Epredia™ Dog1, Mouse Monoclonal Antibody.

DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody1. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase2. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.

Host Species: Mouse

Clone: 1.1

Isotype: Unknown

Species Reactivity: Human. Others not known.

Immunogen: Synthetic peptide of human DOG1

Molecular Weight: 78 kDa

Positive Control: Gastrointestinal Stromal Tumors

Cellular Localization: Cytoplasmic and Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
TRUSTED_SUSTAINABILITY

Specifications

Antígeno Dog1
Aplicaciones Immunohistochemistry
Clon 1.1
Concentración 200μg/mL
Conjugado Unconjugated
Especie del huésped Mouse
Inmunógeno Synthetic peptide of human Dog1
Cantidad 1 mL
Primario o secundario Primary
Especies diana Human
Formulario Purified
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