CD117/c-Kit/SCF-Receptor Ab-3 Mouse Monoclonal Antibody, Epredia™

Descripción

c-kit is a transmembrane receptor tyrosine kinase. It binds to stem cell factor (SCF). It is expressed in many tissues and cells. C-kit/SCf is involved in development of several lineages of stem cells, such as germ cells, neural crest-derived melanocytes and hematopoietic precursor cells. Ab-3 does not interfere with the binding of SCF to c-kit

Host Species: Mouse

Clone: K45

Isotype: IgG2a

Species Reactivity: Human. Others not known.

Epitope: Extracellular second N-terminus Ig-like domain of c-kit

Immunogen: Recombinant human extracellular c-kit fragment

Molecular Weight: 145kDa

Positive Control: Skin, GI Stromal Tumor (GIST)

Cellular Localization: Membrane/cytoplasmic

Recommended for:

• Immunohistochemistry (Frozen or fixed in methacarn or Stieve's and embedded in paraffin)
• Immunofluorescence

Note:

USA: RUO; Int'l: RUO