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Invitrogen™ Mouse L-selectin (SELL) ELISA Kit

ELISA

Marca:  Invitrogen™ EMSELL

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Código de producto. 15485323

  • 682.00€ / 1 set

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Description

Description

The Mouse L-Selectin (SELL) ELISA quantitates Ms L-Selectin in mouse serum, plasma, or cell culture medium. The assay will exclusively recognize both natural and recombinant Ms L-Selectin. Principle of the method The Mouse L-Selectin solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen. Rigorous validation Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.

La CD62L (L-selectina) es una glicoproteína de adhesión con un rango de peso molecular de 74-95 kDa que se expresa constitutivamente en la superficie celular de los leucocitos, y media su orientación hacia los sitios inflamatorios y los ganglios linfáticos periféricos al permitir que se desplacen a lo largo de la pared venular. La CD62L también participa en la agregación de neutrófilos inducida por activación. Sin embargo, el desprendimiento de CD62L dependiente de la activación contrarresta la laminación de neutrófilos. La CD62L también tiene funciones de señalización, incluyendo la mejora de la expresión del receptor de quimiocinas. Al igual que CD62P, el ligando principal de CD62L es PSGL-1 (ligando-1 de glicoproteína P-selectina). Los polimorfismos de un solo nucleótido del gen CD26L se han asociado con diversas enfermedades, como la nefropatía por inmunoglobulina A. Alternativamente, se han encontrado variantes de transcripción empalmadas para CD26L.

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