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Invitrogen™ KREMEN2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ 381700
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Descripción
KREMEN2 Polyclonal Antibody for Western Blot
Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
Especificaciones
| KREMEN2 | |
| Polyclonal | |
| Unconjugated | |
| KREMEN2 | |
| 2900054E04Rik; Dickkopf receptor 2; kremen protein 2; KREMEN2; kringle containing transmembrane protein 2; kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose; Krm2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 73016 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 0.25 mg/mL | |
| PBS with 0.1% sodium azide; pH 7.4 | |
| Q8K1S7 | |
| KREMEN2 | |
| Synthetic peptide derived from the internal region of human, mouse and rat Kremen2 proteins. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
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