Invitrogen™ KIF2A Polyclonal Antibody

Descripción

Immunogen sequence: TSLNEDNESV TVEWIENGDT KGKEIDLESI FSLNPDLVPD EEIEPSPETP PPPASSAKVN KIVKNRRTVA SIKNDPPSRD NRVVGSARAR PSQFPEQSSS AQQNGSVSDI SPVQAAKKEF GPPSRRKSNC VKEVEKLQEK REKRRLQQQE LREKRAQDVD ATNPNYEIMC MIRDFRGSLD YRPLTTADPI D; Positive Samples: Rat brain; Cellular Location: Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle, spindle pole.

KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.