missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ JMJD1A Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA520802
Este artículo no se puede devolver.
Vea la política de devoluciones
Descripción
A suggested positive control is mouse liver tissue lysate. PA5-20802 can be used with blocking peptide PEP-0916.
JMJD1A is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. It's also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
Especificaciones
| JMJD1A | |
| Polyclonal | |
| Unconjugated | |
| KDM3A | |
| 1700105C21Rik; C230043E16Rik; DKFZp686A24246; DKFZp686P07111; JHDM2a; JHMD2A; JmjC domain-containing histone demethylation protein 2A; Jmjd1; Jmjd1a; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1A; jumonji domain-containing protein 1A; KDM2A; Kdm3a; Kiaa0742; lysine (K)-specific demethylase 3A; lysine demethylase 3A; lysine-specific demethylase 3A; probable zinc finger protein; testis specific gene A; testis-specific gene A protein; testis-specific protein A; TGSA; Tsga; zinc finger protein TSGA | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 312440, 55818 | |
| Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| Q63679, Q9Y4C1 | |
| KDM3A | |
| A 16 amino acid peptide from near the amino terminus of human JMJD1A. | |
| 100 μg | |
| Primary | |
| Human, Rat, Rat | |
| Antibody | |
| IgG |
Corrección del contenido de un producto
Proporcione sus comentarios sobre el contenido del producto rellenando el siguiente formulario.
Título del producto
¿Detecta una oportunidad de mejora?Comparta una corrección de contenido