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IRF8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 18977-1-AP-20UL
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Descripción
IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.Especificaciones
| IRF8 | |
| Polyclonal | |
| Unconjugated | |
| IRF8 | |
| H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 15900, 292060, 3394 | |
| -20°C | |
| Liquid |
| Western Blot, Immunohistochemistry (Paraffin) | |
| 1.11 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P23611, Q02556 | |
| IRF8 | |
| Peptide | |
| 20 μL | |
| Primary | |
| Mouse, Rat, Human | |
| Antibody | |
| IgG |
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