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Invitrogen™ IRAK4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA141054
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Descripción
Suggested positive control: antigen standard for IRAK4 (transient overexpression lysate), NIH-3T3 whole cell lysate.
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
Especificaciones
| IRAK4 | |
| Polyclonal | |
| Unconjugated | |
| IRAK4 | |
| 8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64 | |
| Rabbit | |
| Protein G | |
| RUO | |
| 266632, 300177, 51135 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Flow Cytometry, Immunoprecipitation, Western Blot | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| Q8R4K2, Q9NWZ3 | |
| IRAK4 | |
| Mixture of synthetic peptides containing amino acids 38-54 and 120-136 of mouse IRAK-4. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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