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Invitrogen™ IkB zeta Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA530797
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Descripción
Recommended positive controls: HeLa nucleus. Predicted reactivity: Mouse (82%), Dog (86%), Pig (84%), Rabbit (85%), Sheep (85%), Bovine (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
Especificaciones
| IkB zeta | |
| Polyclonal | |
| Unconjugated | |
| NFKBIZ | |
| AA408868; FLJ30225; FLJ34463; Ikappa B-zeta variant 3; ikappaBzeta; I-kappa-B-zeta; IkappaB-zeta; IKBZ; ikB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; Mail; molecule possessing ankyrin repeats induced by lipopolysaccharide; molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKB inhibitor zeta; NFKBIZ; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; OTTHUMP00000214340; RGD1310834 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 64332 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 0.92 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q9BYH8 | |
| NFKBIZ | |
| Recombinant protein encompassing a sequence within the center region of human IKB zeta. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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