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Invitrogen™ ICAM-3 Monoclonal Antibody (MEM-171), Biotin
Description
This antibody recognizes an extracellular epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
Specifications
Specifications
| Antígeno | ICAM-3 |
| Aplicaciones | Flow Cytometry, Immunoprecipitation |
| Clasificación | Monoclonal |
| Clon | MEM-171 |
| Concentración | 1 mg/mL |
| Conjugado | Biotin |
| Formulación | PBS with 15mM sodium azide; pH 7.4 |
| génica | ICAM3 |
| N.º de referencia del gen | P32942 |
| Alias de gen | CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3 |
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