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Invitrogen™ ICAM-1 Polyclonal Antibody

Descripción
Immunogen sequence: EAHPRAKVTL NGVPAQPLGP RAQLLLKATP EDNGRSFSCS ATLEVAGQLI HKNQTRELRV LYGPRLDERD CPGNWTWPEN SQQTPMCQAW GNPLPELKCL KDGTFPLPIG ESVTVTRDLE GTYLCRARST QGEVTRKVTV NVLSP Highest antigen sequence indentity to the following orthologs: Mouse - 55%, Rat - 49%.
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Especificaciones
Especificaciones
| Antígeno | ICAM-1 |
| Aplicaciones | Immunohistochemistry (Paraffin), Western Blot |
| Clasificación | Polyclonal |
| Concentración | 0.10 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| génica | ICAM1 |
| N.º de referencia del gen | P05362 |
| Alias de gen | BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells |
| Símbolos de los genes | ICAM1 |
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Título del producto
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