Invitrogen™ Human Presenilin 2 ELISA Kit
Human Presenilin 2 quantitates human Presenilin 2 in serum, plasma, supernatant.
Marca: Invitrogen™ EH381RBX10
Detalles adicionales : Peso : 2.50000kg
Human Presenilin 2 quantitates human Presenilin 2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Presenilin 2.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
|AD3L; AD3LP; AD4; Ad4h; AD5; Alg3; ALG-3; Alzheimer disease 4; CMD1V; E5-1; presenilin 2; presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS2; Ps-2; PSEN 2; Psen2; Psnl2; STM2; STM-2|
|Colorimetric Microplate Reader|
|Research Use Only|
|2°C to 8°C|
|1 hr 20 min|
|0.2 to 50 ng/mL|
|Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers|
|10 x 96 Tests|
|Supernatant, 50 μL; Serum, 50 μL; Plasma, 50 μL|
|4 hr 45 min|