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Invitrogen™ HLA-G Monoclonal Antibody (MEM-G/2)
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Código de producto. 11564642
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
Código de producto. Cantidad unitSize
11564642 100 μg 100 microgramos
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Código de producto. 11564642

Marca: Invitrogen™ MA119394

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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope on free heavy chain of all the HLA-G isoforms. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells.

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
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Specifications

Antígeno HLA-G
Aplicaciones Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clasificación Monoclonal
Clon MEM-G/2
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 15mM sodium azide; pH 7.4
génica HLA-G
N.º de referencia del gen P17693
Alias de gen acrosomal protein SP-10; Acrosomal vesicle protein 1; ACRV1; b2 microglobulin; D11S4365; DADB-15K14.8; HLA class I histocompatibility antigen, alpha chain G; HLA class I molecule; HLA G antigen; HLA-6.0; HLAG; HLA-G; HLA-G histocompatibility antigen, class I, G; LOC768350; major histocompatibility complex, class I, G; MHC class I antigen G; MHC-G; MHCIY; MHC-like class I Y; sHLA-G; Soluble HLA class I histocompatibility antigen, alpha chain G; SP-10; SPACA2; sperm protein 10
Símbolos de los genes HLA-G
Especie del huésped Mouse
Inmunógeno Bacterially expressed recombinant HLA-G heavy chain (denatured).
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 3135
Especies diana Human
Contenido y almacenamiento 4°C, do not freeze
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1
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