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HLA Class II beta chains (DP, DQ, DR) Mouse anti-Human, Clone: WR18, Abnova™
Mouse monoclonal antibody raised against native human HLA Class II beta chains (DP, DQ, DR).
Marca: Abnova MAB12490.100ug
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Descripción
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq]
Especificaciones
| HLA Class II beta chains (DP, DQ, DR) | |
| Monoclonal | |
| Unconjugated | |
| Flow Cytometry (1:50-1:200) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) The optimal working dilution should be determined by the end user. | |
| DRB1/FLJ76359/HLA-DR1B/HLA-DRB/HLA-DRB1*/SS1 | |
| Mouse | |
| Affinity purification | |
| RUO | |
| 3123/3119/3115 | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
|
| IgG2a |
| Flow Cytometry, Immunohistochemistry (PFA fixed) | |
| WR18 | |
| Mouse monoclonal antibody raised against native human HLA Class II beta chains (DP, DQ, DR). | |
| In PBS (0.09% sodium azide) | |
| HLA-DRB1 | |
| Native purified human HLA Class II beta chains (DP, DQ, DR). | |
| 100 μg | |
| Primary | |
| Human | |
| Liquid |
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